Dr. Mehmet Oz has decided to take on his biggest and sickest patient of all: America.

So far, Dr. Oz has received one endorsement from a prominent GOP member, Rep. “Mehmet Oz has made that decision.

And now it’s up to the residents of Pennsylvania to decide who will represent them.”

Dr. Mehmet Oz

Here’s what that statement from Oprah could really mean.

Is Oprah keeping her distance from Dr. Oz?

Oprah Winfrey’s noncommital statement came as a surprise to many, considering that she was responsible for makingDr.

Oprah Winfrey speaking

Was she simply following her protege’s advice?

“I asked her to stay out,” he said.

But has politics driven a wedge between the two?

By contrast, Dr. Oz is taking a highly conservative approach to the issues in his campaign.

Some think Oprah may also be distancing herself from the doctor over his credibility issues.

The Twitterverse has plenty to say about Oprah’s statement.

Onetweeted, “Have great respect for her success in business.